KEGG pathway - Calcium signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	KCND2 \| Nos1 \| PLCB3 \| Nlgn1 \| TH \| Pln \| Gabrg2 \| Gabrb1 \| ERBB2 \| ITPKA \| EGFR \| HSF1 \| ALOX5 \| ETS1 \| PPP1R14A \| RYR2 \| Myog \| CLCN3 \| HRH1 \| Il6st \| CAMK2A \| Nos1 \| NOS1 \| VIM \| Ryr2 \| Ryr2 \| Trpv1 \| Syn1 \| NEFL \| CALD1 \| TH \| CACNA1S \| Gja1 \| MPZ \| MAPT \| Camk2a \| Mylk \| SRF \| ETS2 \| Lipe \| Creb1 \| CACNA1C \| CACNA1C \| CD44 \| Ptpra \| Spr \| Drd3 \| Gria1 \| Gria4 \| FLNA \| Gjc1 \| TCAP \| MAPT \| Vim \| Dlg4 \| Oprm1 \| Ptk2 \| SPR \| OPRM1 \| SNCA \| GRIA1 \| CDKN1B \| Rph3a \| VIM \| RRAD \| PLN \| Cdk5r1 \| Mecp2 \| Grin2b \| Cacna1c \| Cacna1b \| GFPT1 \| GRIN2B \| ESPL1 \| SMAD2 \| Dlg1 \| Kcnd2 \| Tph2 \| RCHY1 \| CARD11 \| Rims1 \| Pdc \| Lrp4 \| Gabbr1 \| PEA15 \| FBXO43 \| Brsk1 \| SLN \| ITGB1BP1 \| ITGB1 \| Chrm4 \| TNNT2 \| PLN \| CHAT \| GLO1 \| Myh9 \| Sln \| Sln \| \| NCOR2 \| Itpr2 \| HDAC5 \| Mcu \| Mybpc3 \| TH \| Kif3a \| Slc6a3 \| STMN1 \| Cpeb3 \| KIF3A \| Ppp3ca \| DAGLA \| Abi1 \| NOX5 \| SLC6A4 \| Syngap1 \| KCNQ2 \| Neto2 \| CTNNB1 \| BECN1 \| DLGAP1 \| Wee2 \| ID1 \| Fosb \| NR1H2 \| Psmc5 \| KCNJ11 \| Grm1 \| SLC1A3 \| Trpc6 \| Dpysl2 \| TNNT2 \| DLG1 \| GABRG2 \| PDC \| CLCN3 \| PTPRA \| BCL10 \| KRT18 \| MAPT \| MAPT \| CREB1 \| ATP2A2 \| PTPRA \| PDC \| DRD3 \| DLG1 \| IRF3 \| ABI1 \| HOMER3 \| RYR2 \| TRPV1 \| SYN1 \| NEFL \| CACNA1S \| \| MPZ \| CAMK2A \| CALD1 \| CALD1 \| \| CACNA1C \| CACNA1C \| GRIA4 \| \| GJC1 \| MAPT \| NOS1 \| DLG4 \| PTK2 \| RPH3A \| GABRB1 \| CDK5R1 \| IL6ST \| MECP2 \| CACNA1B \| KCND2 \| TPH2 \| RIMS1 \| LRP4 \| \| PEA15 \| \| GFAP \| \| PDC \| SYNGAP1 \| MCU \| MYBPC3 \| KIF3A \| SLC6A3 \| CPEB3 \| PPP3CA \| FOSB \| \| ATP2A2 \| CEBPB \| CFL2 \| ADCY3 \| QDPR \| GFAP \| ACACA \| RYR1 \| PPP1R9B \| MYLK \| ITGB1BP1 \| CHAT \| BRSK1 \| CHRM4 \| MYF4 \| SLN \| nlgn1 \| GRM1 \| TRPC6 \| \| VPS72 \| \|
CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta;	Q13554	Gsk3b \| RYR1 \| CAMK2B \| STMN1 \| Gsk3a \| PRKAA1 \| DLGAP1 \| OCLN \| GRIN2B \| GSK3A \| GSK3B \| TH \| CREB1 \| ATP2A2 \| CEBPB \| FLNA \| PEA15 \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| GRIA1 \| HSF1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| RYR1 \| VIM \| RYR2 \| PPP3CA \| OPRM1 \| PPP1R9B \| PLN \| CAMK2B \| VPS72 \| \| CAMK2A \|
CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta;	Q13557	Ryr2 \| ANKRD28 \| HDAC4 \| SCN5A \| CACNB2 \| Itpr2 \| Pln \| CEACAM1 \| TTN \| OCLN \| KCNJ11 \| VIM \| CREB1 \| TPD52 \| HSF1 \| ITPR2 \| HIST3H3 \| SSH1 \| RYR2 \| HDAC5 \| RYR2 \| PLN \| TH \| ATP2A2 \| CEBPB \| FLNA \| PEA15 \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| GRIA1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| RYR1 \| PPP3CA \| GRIN2B \| OPRM1 \| PPP1R9B \| CAMK2D \| VPS72 \| \| CAMK2A \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma;	Q13555	Bad \| STAT3 \| RELA \| RARA \| CAMK2G \| DAB2 \| OCLN \| RRAD \| BAD \| \| \| TH \| \| RYR1 \| STAT1 \| GRIA1 \| PEA15 \| CREB1 \| ATP2A2 \| CEBPB \| FLNA \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| HSF1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| VIM \| RYR2 \| PPP3CA \| GRIN2B \| OPRM1 \| PPP1R9B \| VPS72 \| PLN \| \| CAMK2A \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	EP300 \| Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Camk4 \| HDAC4 \| CREBBP \| Hspb1 \| MYL12A \| RELA \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|
MYLK	Myosin light chain kinase, smooth muscle;	Q15746	MYL9 \| MYL12B \| CALD1 \| Myl12b \| MYL2 \| CALD1 \| MYLK \| CALD1 \|
MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle;	Q9H1R3	MYL9 \| MYL12A \| MYL12B \| MEF2C \|
MYLK3	Myosin light chain kinase 3;	Q32MK0	Ppp1r2 \| PPP1R2B \|
PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform;	Q16816	GAP43 \| NRGN \| GAP43 \| MAPT \| MAPT \| MAPT \| NRGN \| PYGM \| PYGB \| PHKG1 \| PHKA1 \| TNNT3 \| TNNI3 \| TNNI2 \|
PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform;	P15735	PHKG1 \| PYGM \| PYGB \| PHKA1 \| MAPT \| TNNT3 \| TNNI3 \| TNNI2 \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	KCND2 \| Nos1 \| PLCB3 \| Nlgn1 \| TH \| Pln \| Gabrg2 \| Gabrb1 \| ERBB2 \| ITPKA \| EGFR \| HSF1 \| ALOX5 \| ETS1 \| PPP1R14A \| RYR2 \| Myog \| CLCN3 \| HRH1 \| Il6st \| CAMK2A \| Nos1 \| NOS1 \| VIM \| Ryr2 \| Ryr2 \| Trpv1 \| Syn1 \| NEFL \| CALD1 \| TH \| CACNA1S \| Gja1 \| MPZ \| MAPT \| Camk2a \| Mylk \| SRF \| ETS2 \| Lipe \| Creb1 \| CACNA1C \| CACNA1C \| CD44 \| Ptpra \| Spr \| Drd3 \| Gria1 \| Gria4 \| FLNA \| Gjc1 \| TCAP \| MAPT \| Vim \| Dlg4 \| Oprm1 \| Ptk2 \| SPR \| OPRM1 \| SNCA \| GRIA1 \| CDKN1B \| Rph3a \| VIM \| RRAD \| PLN \| Cdk5r1 \| Mecp2 \| Grin2b \| Cacna1c \| Cacna1b \| GFPT1 \| GRIN2B \| ESPL1 \| SMAD2 \| Dlg1 \| Kcnd2 \| Tph2 \| RCHY1 \| CARD11 \| Rims1 \| Pdc \| Lrp4 \| Gabbr1 \| PEA15 \| FBXO43 \| Brsk1 \| SLN \| ITGB1BP1 \| ITGB1 \| Chrm4 \| TNNT2 \| PLN \| CHAT \| GLO1 \| Myh9 \| Sln \| Sln \| \| NCOR2 \| Itpr2 \| HDAC5 \| Mcu \| Mybpc3 \| TH \| Kif3a \| Slc6a3 \| STMN1 \| Cpeb3 \| KIF3A \| Ppp3ca \| DAGLA \| Abi1 \| NOX5 \| SLC6A4 \| Syngap1 \| KCNQ2 \| Neto2 \| CTNNB1 \| BECN1 \| DLGAP1 \| Wee2 \| ID1 \| Fosb \| NR1H2 \| Psmc5 \| KCNJ11 \| Grm1 \| SLC1A3 \| Trpc6 \| Dpysl2 \| TNNT2 \| DLG1 \| GABRG2 \| PDC \| CLCN3 \| PTPRA \| BCL10 \| KRT18 \| MAPT \| MAPT \| CREB1 \| ATP2A2 \| PTPRA \| PDC \| DRD3 \| DLG1 \| IRF3 \| ABI1 \| HOMER3 \| RYR2 \| TRPV1 \| SYN1 \| NEFL \| CACNA1S \| \| MPZ \| CAMK2A \| CALD1 \| CALD1 \| \| CACNA1C \| CACNA1C \| GRIA4 \| \| GJC1 \| MAPT \| NOS1 \| DLG4 \| PTK2 \| RPH3A \| GABRB1 \| CDK5R1 \| IL6ST \| MECP2 \| CACNA1B \| KCND2 \| TPH2 \| RIMS1 \| LRP4 \| \| PEA15 \| \| GFAP \| \| PDC \| SYNGAP1 \| MCU \| MYBPC3 \| KIF3A \| SLC6A3 \| CPEB3 \| PPP3CA \| FOSB \| \| ATP2A2 \| CEBPB \| CFL2 \| ADCY3 \| QDPR \| GFAP \| ACACA \| RYR1 \| PPP1R9B \| MYLK \| ITGB1BP1 \| CHAT \| BRSK1 \| CHRM4 \| MYF4 \| SLN \| nlgn1 \| GRM1 \| TRPC6 \| \| VPS72 \| \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	KCND2 \| Nos1 \| PLCB3 \| Nlgn1 \| TH \| Pln \| Gabrg2 \| Gabrb1 \| ERBB2 \| ITPKA \| EGFR \| HSF1 \| ALOX5 \| ETS1 \| PPP1R14A \| RYR2 \| Myog \| CLCN3 \| HRH1 \| Il6st \| CAMK2A \| Nos1 \| NOS1 \| VIM \| Ryr2 \| Ryr2 \| Trpv1 \| Syn1 \| NEFL \| CALD1 \| TH \| CACNA1S \| Gja1 \| MPZ \| MAPT \| Camk2a \| Mylk \| SRF \| ETS2 \| Lipe \| Creb1 \| CACNA1C \| CACNA1C \| CD44 \| Ptpra \| Spr \| Drd3 \| Gria1 \| Gria4 \| FLNA \| Gjc1 \| TCAP \| MAPT \| Vim \| Dlg4 \| Oprm1 \| Ptk2 \| SPR \| OPRM1 \| SNCA \| GRIA1 \| CDKN1B \| Rph3a \| VIM \| RRAD \| PLN \| Cdk5r1 \| Mecp2 \| Grin2b \| Cacna1c \| Cacna1b \| GFPT1 \| GRIN2B \| ESPL1 \| SMAD2 \| Dlg1 \| Kcnd2 \| Tph2 \| RCHY1 \| CARD11 \| Rims1 \| Pdc \| Lrp4 \| Gabbr1 \| PEA15 \| FBXO43 \| Brsk1 \| SLN \| ITGB1BP1 \| ITGB1 \| Chrm4 \| TNNT2 \| PLN \| CHAT \| GLO1 \| Myh9 \| Sln \| Sln \| \| NCOR2 \| Itpr2 \| HDAC5 \| Mcu \| Mybpc3 \| TH \| Kif3a \| Slc6a3 \| STMN1 \| Cpeb3 \| KIF3A \| Ppp3ca \| DAGLA \| Abi1 \| NOX5 \| SLC6A4 \| Syngap1 \| KCNQ2 \| Neto2 \| CTNNB1 \| BECN1 \| DLGAP1 \| Wee2 \| ID1 \| Fosb \| NR1H2 \| Psmc5 \| KCNJ11 \| Grm1 \| SLC1A3 \| Trpc6 \| Dpysl2 \| TNNT2 \| DLG1 \| GABRG2 \| PDC \| CLCN3 \| PTPRA \| BCL10 \| KRT18 \| MAPT \| MAPT \| CREB1 \| ATP2A2 \| PTPRA \| PDC \| DRD3 \| DLG1 \| IRF3 \| ABI1 \| HOMER3 \| RYR2 \| TRPV1 \| SYN1 \| NEFL \| CACNA1S \| \| MPZ \| CAMK2A \| CALD1 \| CALD1 \| \| CACNA1C \| CACNA1C \| GRIA4 \| \| GJC1 \| MAPT \| NOS1 \| DLG4 \| PTK2 \| RPH3A \| GABRB1 \| CDK5R1 \| IL6ST \| MECP2 \| CACNA1B \| KCND2 \| TPH2 \| RIMS1 \| LRP4 \| \| PEA15 \| \| GFAP \| \| PDC \| SYNGAP1 \| MCU \| MYBPC3 \| KIF3A \| SLC6A3 \| CPEB3 \| PPP3CA \| FOSB \| \| ATP2A2 \| CEBPB \| CFL2 \| ADCY3 \| QDPR \| GFAP \| ACACA \| RYR1 \| PPP1R9B \| MYLK \| ITGB1BP1 \| CHAT \| BRSK1 \| CHRM4 \| MYF4 \| SLN \| nlgn1 \| GRM1 \| TRPC6 \| \| VPS72 \| \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma;	Q13555	Bad \| STAT3 \| RELA \| RARA \| CAMK2G \| DAB2 \| OCLN \| RRAD \| BAD \| \| \| TH \| \| RYR1 \| STAT1 \| GRIA1 \| PEA15 \| CREB1 \| ATP2A2 \| CEBPB \| FLNA \| CFL2 \| DLG1 \| ADCY3 \| KRT18 \| QDPR \| GFAP \| HSF1 \| PLCB3 \| KCND2 \| SYN1 \| ACACA \| VIM \| RYR2 \| PPP3CA \| GRIN2B \| OPRM1 \| PPP1R9B \| VPS72 \| PLN \| \| CAMK2A \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	EP300 \| Creb1 \| Myh9 \| HDAC5 \| Crebbp \| CAMK4 \| HNRNPL \| STMN1 \| SIK2 \| PHB2 \| CABIN1 \| SRF \| CREB1 \| CAMK2A \| Crebbp \| LIMK1 \| Camk4 \| HDAC4 \| CREBBP \| Hspb1 \| MYL12A \| RELA \| Snf1lk2 \| NUMB \| HSPB1 \| NOS1 \| ACACA \| SYN1 \| SNF1LK2 \| CAMK1 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	CAMK2A \|
CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta;	Q13554	CAMK2B \|
CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta;	Q13557	CAMK2D \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma;	Q13555	CAMK2G \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
MYLK	Myosin light chain kinase, smooth muscle;	Q15746	MYLK \|
MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle;	Q9H1R3	MAPKAPK2 \|
PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform;	Q16816	PHKG2 \| PHKG1 \|
CACNA1C	Voltage-dependent L-type calcium channel subunit alpha-1C;	Q13936	CAMK2A \| PRKD1 \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	CAMK2A \|
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha;	Q9UQM7	CAMK2A \|
CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma;	Q13555	CAMK2G \|
CAMK4	Calcium/calmodulin-dependent protein kinase type IV;	Q16566	CAMKK1 \| CAMK4 \| CAMK1 \|
EGFR	Epidermal growth factor receptor;	P00533	PRKD1 \| CAMK2A \| PRKAA1 \|
ERBB2	Receptor tyrosine-protein kinase erbB-2;	P04626	CAMK2A \| PRKAA1 \|
HRH1	Histamine H1 receptor;	P35367	CAMK2A \|
ITPKA	Inositol-trisphosphate 3-kinase A;	P23677	CAMK2A \|
NOS1	Nitric oxide synthase, brain;	P29475	CAMK2A \| CAMK1 \|
NOS3	Nitric oxide synthase, endothelial;	P29474	PRKAA1 \| Prkaa2 \| Prkaa1 \| PRKAA2 \|
PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3;	Q01970	CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \|
PLN	Cardiac phospholamban;	P26678	CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \|
RYR2	Ryanodine receptor 2;	Q92736	CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \|
SPHK2	Sphingosine kinase 2;	Q9NRA0	PRKD1 \| PRKD3 \|