KEGG pathway - mTOR signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	Tbc1d4 \| IKBKB \| HDAC5 \| FOXO3 \| Vasp \| PLD1 \| HAS2 \| SIRT1 \| TP73 \| Tp53 \| Ppargc1a \| Kcnb1 \| ACACA \| PARP1 \| EEF2K \| DUSP1 \| Parp1 \| GLI1 \| TFAP2A \| Prkaa2 \| PPARGC1A \| PFKFB2 \| ULK1 \| NOS3 \| CTNNB1 \| ACACA \| ACACA \| CRTC2 \| TBC1D1 \| TP53 \| KCNB1 \| VASP \| TBC1D4 \| ACACB \| PARP1 \| FYN \| PPARGC1A \| \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	PPP1R3A \| ESR2 \| CEBPB \| BAD \| ETV1 \| NFKBIB \| IRS1 \| EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| TSC2 \| Tsc2 \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2;	Q15349	BAD \| CREB1 \| RRN3 \| CDKN1B \| ATF4 \| Atf4 \| NFATC4 \| DAPK1 \| MEF2C \| FOS \| RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3;	P51812	Mybpc3 \| PFKFB2 \| CIC \| KCNK3 \| ESR1 \| EIF2S1 \| Nr4a1 \| Htr2a \| Creb1 \| ATF4 \| EIF2AK2 \| Cebpb \| NFKBIA \| HIST1H2BB \| STAT3 \| Gata4 \| CDKN1B \| GSK3A \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| PPP1R3A \| NFATC4 \| RRN3 \| CREB1 \| HMGN1 \| TH \| TH \| TH \| PFKFB2 \| Mybpc3 \| Rps6 \| HIST1H3A \| H3F3A \| PPP1R3A \| BAD \| RANBP3 \| MAP3K5 \| WWC1 \| TH \| TINF2 \| LCP1 \| TBX21 \| FGFR1 \| STMN1 \| EPHA2 \| SLC9A3 \| CASP8 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	TP53 \| MBP \| Prkaa1 \| MELK \| STK11 \| BRSK1 \| PTEN \| MARK3 \| PRKAA2 \| SNRK \| BRSK1 \| BRSK2 \| MARK1 \| MARK2 \| MARK4 \| NUAK2 \| NUAK1 \| SIK1 \| SIK2 \| STRADA \| SMAD4 \| PAK1 \| SIK3 \| Stk11 \| SIK3 \| MARK3 \| Sik1 \| ETV4 \| GSK3B \| SIK1B \| \| STK11 \| SNRK \| MARK1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	PRKAB1 \| PPP1R3C \| Slc12a1 \| RRN3 \| ACACA \| KLC2 \| Gabbr1 \| Mlxipl \| Mtor \| ZNF692 \| EEF2K \| ACACB \| ULK1 \| Gabbr2 \| Mylk \| Rb1 \| TNNI3 \| NOS3 \| NOS3 \| CSNK1E \| Tsc2 \| Kcnj11 \| Cry1 \| GFPT1 \| Kcnma1 \| PPP2R5C \| PFKFB3 \| TBC1D1 \| Cdkn1b \| CDKN1B \| VASP \| Med1 \| FOXO3 \| EP300 \| HDAC5 \| Kcnb1 \| CFTR \| CTBP1 \| KPNA2 \| GBF1 \| PFKFB2 \| Ulk1 \| TP53 \| Lipe \| HNF4A \| Tsc2 \| LIPE \| GFPT1 \| KLC1 \| PRKAA1 \| SLC12A1 \| RPTOR \| ATG9A \| Nfe2l2 \| Pde4b \| Foxo3 \| NET1 \| FH \| Tnni3 \| SNX17 \| GAPDH \| JAK1 \| YAP1 \| EPM2A \| Sqstm1 \| Atp6v1a \| MAPT \| GLI1 \| DDIT3 \| PRPS2 \| PPP1R12C \| Med1 \| PRPS1 \| PIAS1 \| USP10 \| MKNK1 \| Braf \| FANCA \| KIF4A \| TP73 \| Pnpla2 \| Gatad2a \| SREBF1 \| TXNIP \| CGN \| POU2F1 \| BRAF \| SYK \| ACSS2 \| Nr2c2 \| SQSTM1 \| Map4 \| RACK1 \| PAQR3 \| EGFR \| ERBB2 \| BECN1 \| Cnbp \| EZH2 \| SIRT2 \| CTTN \| FOXO1 \| CYCS \| CNBP \| NFE2L2 \| MYLK \| \| \| RAF1 \| MAPT \| GYS2 \| ACACA \| ACACA \| GABBR2 \| RB1 \| \| KCNB1 \| NOS3 \| TSC2 \| TSC2 \| CRY1 \| KCNMA1 \| MLXIPL \| GABBR1 \| \| ATP6V1A \| MED1 \| BRAF \| PNPLA2 \| GATAD2A \| NR2C2 \| MAP4 \| TSC2 \| PRKCQ \| MTOR \| CYCS \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	PPP1R3A \| ESR2 \| CEBPB \| BAD \| ETV1 \| NFKBIB \| IRS1 \| EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| TSC2 \| Tsc2 \| GSK3B \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	TP53 \| MBP \| Prkaa1 \| MELK \| STK11 \| BRSK1 \| PTEN \| MARK3 \| PRKAA2 \| SNRK \| BRSK1 \| BRSK2 \| MARK1 \| MARK2 \| MARK4 \| NUAK2 \| NUAK1 \| SIK1 \| SIK2 \| STRADA \| SMAD4 \| PAK1 \| SIK3 \| Stk11 \| SIK3 \| MARK3 \| Sik1 \| ETV4 \| GSK3B \| SIK1B \| \| STK11 \| SNRK \| MARK1 \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2;	P54646	STK11 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	MAPKAPK2 \| RPS6KA1 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2;	Q15349	RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3;	P51812	MAPKAPK2 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	STK11 \|
AKT1	RAC-alpha serine/threonine-protein kinase;	P31749	MAPKAPK2 \| SIK2 \| CAMKK2 \| PRKD1 \|
EIF4B	Eukaryotic translation initiation factor 4B;	P23588	PIM1 \| PIM2 \| MELK \| RPS6KA1 \|
EIF4E	Eukaryotic translation initiation factor 4E;	P06730	MKNK2 \| MKNK1 \|
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1;	Q13131	Prkaa1 \| CAMK2B \| BRSK1 \| BRSK2 \| CAMKK1 \| CAMKK2 \| PRKAA1 \| PRKD1 \|
RPS6	40S ribosomal protein S6;	P62753	RPS6KA3 \| DAPK1 \| PASK \| RPS6KA1 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1;	Q15418	MAPKAPK2 \| RPS6KA1 \|
RPTOR	Regulatory-associated protein of mTOR;	Q8N122	Prkaa1 \| Prkaa2 \| PRKAA1 \| RPS6KA1 \|
STK11	Serine/threonine-protein kinase STK11;	Q15831	STK11 \|
STRADA	STE20-related kinase adapter protein alpha;	Q7RTN6	STK11 \|
TSC2	Tuberin;	P49815	MAPKAPK2 \| PIM2 \| BRSK2 \| RPS6KA1 \|
ULK1	Serine/threonine-protein kinase ULK1;	O75385	PRKAA1 \| PRKAA2 \|